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Not medical advice. Trial Beacon is a pre-screening tool. Eligibility determinations are made by clinical investigators, not by this application. Discuss any trial with your care team before acting on it.

© 2026 Trial Beacon · A pre-screening tool

Trial Beacon

Oncology clinical trials,
made legible.

Search active cancer trials by condition, location, and phase. Every listing links to the full protocol — no sign-in required.

6,126 trials match these filters.

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  • Phase I·NCT07544992·Recruiting

    Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

    This phase I trial studies the side effects and best dose of EGFR/IL13Rα2 pool-chimeric antigen receptor (CAR) T cells when given through a thin, flexible tube into the brain (locoregional administration) in treating patients with high-grade gliomas that have…

    • Recurrent Astrocytoma, Idh-mutant, Grade 4
    • Recurrent Glioblastoma, Idh-wildtype
    • Astrocytoma
    • +1 more
    1 site
  • Phase I·NCT05099003·Recruiting

    A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

    This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG)…

    • Malignant Glioma
    • Glioma
    127 sites
  • N/A·NCT06930521·Recruiting

    JUdicious Surveillance for Trastuzumab Induced Cardiotoxicity in the First Year

    This study focuses on male and female patients being treated for breast cancer that is positive for the HER2 receptor which requires special treatments targeting that receptor. The problem is that these treatments, while effective for the cancer, can…

    • Cardiovascular Health
    • Breast Cancer
    • Breast Cancer Early Stage Breast Cancer (stage 1-3)
    • +7 more
    1 site
  • N/A·NCT07644091·Recruiting

    Psychosocial Burden and Quality of Life in Caretakers of Hepatobiliary Cancer Patients

    Assess caregiver psychosocial burden, including Quality of Life, health, interpersonal relationship, access to support, and explore associated sociodemographic and contextual factors.

    • Psychosocial Problem
    1 site
  • N/A·NCT04658303·Recruiting

    Evolution of Metabolic and Immune Dysfunction in In-transit Melanoma

    Melanoma in-transit metastases (ITMs) continue to represent a therapeutic dilemma, in that no standard method of treatment has been uniformly adopted. The complexity and heterogeneity of patient and disease characteristics, including the location and number…

    • Melanoma
    • Immune System Diseases
    1 site
  • Phase I·NCT03609580·Recruiting

    Post-operative Urinary Retention (POUR) Following Thoracic Surgery

    Inability to urinate a common complication that happens to many patients after a surgery, especially in men over 60 years of age who undergo surgery on their chest. Urinary retention is uncomfortable, increases anxiety, increases hospital length of stay, and…

    • Urinary Retention
    • Lung Neoplasms
    1 site
  • Phase I·NCT07297979·Recruiting

    Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

    The main objectives of this trial are to determine the recommended dose for expansion of xaluritamig (dose confirmation part only) and to determine the safety and tolerability of xaluritamig in adult, adolescent and pediatric participants with relapsed or…

    • Ewing Sarcoma
    • Sarcoma, Ewing
    • Recurrence
    7 sites
  • Phase II·NCT03907475·Recruiting

    Durvalumab in Combination With Chemotherapy in Treating Patients With Advanced Solid Tumors, DURVA+ Trial

    This phase II trial studies the side effects of durvalumab when given together with chemotherapy in treating patients with solid tumors that have spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as durvalumab, may…

    • Locally Advanced Malignant Solid Neoplasm
    • Metastatic Malignant Solid Neoplasm
    • Neoplasm Metastasis
    1 site
  • N/A·NCT00001823·Recruiting

    Evaluation for NCI Surgery Branch Clinical Research Protocols

    Background: The National Cancer Institute Surgery Branch (NCI-SB) has developed experimental therapies that involve taking white blood cells from patients' tumor or from their blood, growing them in the laboratory in large numbers, and then giving the cells…

    • Synovial Cell Cancer
    • Melanoma
    • Colorectal Cancer
    • +6 more
    1 site
  • Phase I·NCT07439653·Recruiting

    A Study of TORL-5-700 in Relapsed/Refractory Non Hodgkin's Lymphoma

    A Phase 1/2 study to evaluate safety, tolerability, and anticancer activity of TORL-5-700 as a monotherapy and in combination in R/R NHL

    • Histologically Confirmed Relapsed Or Refractory B-cell Non-hodgkin Lymphoma
    • Lymphoma, B-cell
    3 sites
  • Phase I·NCT05803382·Recruiting

    Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

    This phase I trial tests the safety, side effects, and best dose of ZEN003694 in combination with the usual treatment with capecitabine in treating patients with cancer that has spread from where it first started (primary site) to other places in the body…

    • Metastatic Colorectal Carcinoma
    • Metastatic Malignant Solid Neoplasm
    • Stage Iv Colorectal Cancer Ajcc V8
    • +4 more
    22 sites
  • Phase II·NCT05419076·Recruiting

    A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

    The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.

    • Lung Cancer
    • Lung Cancer Metastatic
    • Brain Metastases
    • +5 more
    7 sites
  • Phase I·NCT06568094·Recruiting

    A Study of HRS-5041 Tablets Combined With Antitumor Therapy in Subjects With Advanced Prostate Cancer

    The purpose of this study is to evaluate the efficacy, and safety of HRS-5041 tablets combined with antitumor therapy in subjects with advanced prostate cancer.

    • Prostate Cancer
    • Prostatic Neoplasms
    2 sites
  • Phase I·NCT04167969·Recruiting

    The Use of Nanoparticles to Guide the Surgical Treatment of Prostate Cancer

    The purpose of this study is to see whether using the copper-64 (64Cu) or zirconium-89 (89Zr) radiolabeled PSMA-targeting C' dot tracer, termed 64Cu-NOTA-PSMAi-PEG-Cy5.5-C' dots or 89Zr-DFO-PSMAi-PEG-Cy5.5-C' dots, is a safe way to identify tumor cells before…

    • Prostate Cancer
    • Prostatic Neoplasms
    2 sites
  • Phase II·NCT06087861·Recruiting

    5-Day Preoperative Radiation for Soft Tissue Sarcoma

    The purpose of this study is to examine the safety and efficacy of an abbreviated course of preoperative radiation, given over five days, for patients with soft tissue sarcoma of the extremity, trunk or retroperitoneum. This is in contrast to standard…

    • Soft Tissue Sarcoma
    • Sarcoma
    1 site
  • Phase I·NCT06914128·Recruiting

    A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

    The study treatment, BAY 3713372, is under development to treat MTAP (methylthioadenosine phosphorylase)-deleted solid tumors. It is thought to work by blocking the protein arginine N-methyltransferase 5 (PRMT5). This may kill the MTAP-deleted cancer cells…

    • Mtap-deleted Solid Tumors
    • Carcinoma, Non-small-cell Lung
    • Glioblastoma
    60 sites
  • Phase II·NCT05758688·Recruiting

    PROton Therapy for Post Surgical Treatment of GYNecologic Cancer

    This is a single institution, multi-center, Phase II, single-arm study, using Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT) in the post-surgical, adjuvant setting for definitive treatment of gynecologic cancers. The purpose of this study…

    • Cervical Cancer
    • Uterine Cancer
    • Endometrial Cancer
    • +3 more
    3 sites
  • N/A·NCT07637474·Recruiting

    Immune Metabolism Dysregulation and Efficacy to Anti-PD-1 PD-L1 Agents in Non Small Cell Lung Cancer Patients

    Prospective, biological, observational study involving the collection and use of samples from patients suffering from NSCLC lung cancer, aimed at comparing the molecular profile related to metabolism among subjects with response or resistance to checkpoint…

    • Nsclc
    • Carcinoma, Non-small-cell Lung
    1 site
  • N/A·NCT06314672·Recruiting

    Outreach Project to Connect Underrepresented Populations to Clinical Trials at Ohio State University, CUSP2CT Project Trial

    This clinical trial tests the impact of the The Ohio State University Connecting Underrepresented Populations to Clinical Trials (CUSP2CT) project on clinical trial referrals and enrollment in racial/ethnic minorities. Progress in cancer prevention, detection…

    • Hematopoietic And Lymphoid System Neoplasm
    • Malignant Solid Neoplasm
    1 site
  • N/A·NCT06015932·Recruiting

    Group Cognitive Behavior Sessions (CBCSM) to Decrease Distress in Cancer Patients

    This clinical trial tests how well cognitive behavioral cancer stress management (CBCSM) group sessions work to decrease psychological distress in cancer patients. CBCSM teaches patients how to recognize and reduce the impacts of cancer associated stress on…

    • Hematopoietic And Lymphoid System Neoplasm
    • Malignant Solid Neoplasm
    • Metastatic Malignant Solid Neoplasm
    • +1 more
    1 site

1–20of6,126trials

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